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Publications 2025

Gonzalez, Victoria; Lobb, Briallen; Cote, Jacob; Bhuinya, Arkadeb; Tubb, Adriana, G.; Nuthalapati, Stephen, S.; Asavajaru, Akarin; Zhou, Yan; Misra, Vikram; Falzarano, Darryl; Sweeney, Trevor, R.; Gobeil, Sophie M., C.; Wang, Linfa; Doxey, Andrew, C.; Banerjee, Arinjay. (2025) Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity. NATURE COMMUNICATIONS. DOI 10.1038/s41467-025-61254-7 (http://dx.doi.org/10.1038/s41467-025-61254-7)

Paquin, Pascal; DeGrace, Nicolas; Belanger-Chabot, Guillaume; Paquin, Jean-Francois. (2025) Gold-Catalyzed Synthesis of Substituted 4-Pentafluorosulfanyl-1,3-Oxazoles. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. DOI 10.1002/ejoc.202500348 (http://dx.doi.org/10.1002/ejoc.202500348)

Bahadori, Sam; Grosset-Magagne, Mathilde; Giguere, Denis. (2025) Synthesis of Rare-Bacterial Sugar Analogs: Thomosamine and Fluorinated Thomosamine. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. DOI 10.1002/ejoc.202500523 (http://dx.doi.org/10.1002/ejoc.202500523)

Fortier, David; Seguin, Jean-Christophe; Voyer, Normand. (2025) Characterization of the Volatile Compounds of the Hardwood Portion of Betula papyrifera Marshall From Quebec, Canada. CHEMISTRY & BIODIVERSITY. DOI 10.1002/cbdv.202501398 (http://dx.doi.org/10.1002/cbdv.202501398)

Lessard, Olivier; Grosset-Magagne, Mathilde; Metrangolo, Pierangelo; Giguere, Denis. (2025) Synthesis and Conformational Analysis of Pyran Interhalide Analogues of Galactose, Mannose, Talose, and Glucose. CHEMISTRY-A EUROPEAN JOURNAL. DOI 10.1002/chem.202501689 (http://dx.doi.org/10.1002/chem.202501689)

Scarrone, Martina; Turner, Dann; Wittmann, Johannes; Rohde, Christine; Labrie, Simon, J.; Tremblay, Denise, M.; Moineau, Sylvain. (2025) Complete genome of five Acinetobacter baumannii phages. MICROBIOLOGY RESOURCE ANNOUNCEMENTS. DOI 10.1128/mra.00463-25 (http://dx.doi.org/10.1128/mra.00463-25)

Jain, Kanishk; Tchara, Pata-Eting, Kougnassoukou; Khan, Abid; Mengistalem, Amanuel, B.; Holland, Aidan, P.; Bowman, Christopher, N.; Marunde, Matthew, R.; Engel, Tiffany, A.; Popova, Irina, K.; Cooke, Spencer, W.; Krajewski, Krzysztof; Keogh, Michael-Christopher; Lambert, Jean-Philippe; Strahl, Brian, D. (2025) Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response. NUCLEIC ACIDS RESEARCH. DOI 10.1093/nar/gkaf666 (http://dx.doi.org/10.1093/nar/gkaf666)

Batool, Zahra; Dutt, Shireen, Mona; al-Rashida, Mariya; Gelsleichter, Nicolly, Espindola; Pelletier, Julie; Sevigny, Jean; Islam, Talha; Aftab, Hina; Almutairi, Tahani, Mazyad; Cakir, Furkan; Shafiq, Zahid; Iqbal, Jamshed. (2025) N-hexylsulfonyl indole based thiosemicarbazones as potent and selective ecto-5′-nucleotidase and NTPDase inhibitors. BIOORGANIC CHEMISTRY. DOI 10.1016/j.bioorg.2025.108717 (http://dx.doi.org/10.1016/j.bioorg.2025.108717)

Burchell-Reyes, Kelly; Depoumps, Chloe; Paquin, Jean-Francois. (2025) Noyori-Ikariya Asymmetric Transfer Hydrogenation of Prochiral α-CF3 and α-SF5 Ketones. ACS ORGANIC & INORGANIC AU. DOI 10.1021/acsorginorgau.5c00038 (http://dx.doi.org/10.1021/acsorginorgau.5c00038)

Teixeira, Maxime; Sheta, Razan; Musiol, Dylan; Ranjakasoa, Vetso; Loehr, Jeremy; Lambert, Jean-Philippe; Oueslati, Abid. (2025) Combining light-induced aggregation and biotin proximity labeling implicates endolysosomal proteins in early α-synuclein oligomerization. ISCIENCE. DOI 10.1016/j.isci.2025.112823 (http://dx.doi.org/10.1016/j.isci.2025.112823)

Seguin, Jean-Christophe; Mahannah, Chelsea; Voyer, Normand. (2025) Characterization and Variability Analysis of Volatile Metabolites From Acer saccharum Leaves From Québec Region. CHEMISTRY & BIODIVERSITY. DOI 10.1002/cbdv.202501201 (http://dx.doi.org/10.1002/cbdv.202501201)

Pinto-Cardoso, Rui; Bessa-Andres, Catarina; Pereira-Costa, Flavio; Neiva, Rafael; Martins-Ferreira, Ricardo; Guerra-Leal, Barbara; Nobrega Catelas, Diogo; Vilaca,, Adelio; Oliveira, Antonio; Pelletier, Julie; Sevigny, Jean; Noronha-Matos, Jose, Bernardo; Correia-de-Sa, Paulo. (2025) HIF-1α Stabilization Hampers the Chondrogenic Differentiation of Aged Bone Marrow Mesenchymal Stem Cells by Adenosine A2A/A2B Receptors Imbalance. ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE. DOI 10.1021/acsptsci.5c00190 (http://dx.doi.org/10.1021/acsptsci.5c00190)

Kelestemur, Taha; Robson, Simon, C.; Nemeth, Zoltan, H.; Pacher, Pal; Arif, Muhammed; Aydin, Mehmet, S.; Suzek, Baris, E.; Pelletier, Julie; Lunsford, Keri, E.; Schwabe, Robert, F.; Geng, Yana; Sevigny, Jean; Hasko, Gyorgy. (2025) NTPDase8 Protects Against Liver Ischemia-Reperfusion Injury in Mice. FASEB JOURNAL. DOI 10.1096/fj.202500010RR (http://dx.doi.org/10.1096/fj.202500010RR)

Raiche-Marcoux, Gabrielle; Guerin, Sylvain; Boisselier, Elodie. (2025) Cellular models used to study the pathogenesis associated with ocular inflammation in the anterior part of the eye. M S-MEDECINE SCIENCES. DOI 10.1051/medsci/2025046 (http://dx.doi.org/10.1051/medsci/2025046)

Loiseau, Alexis; Gross, Christelle; Guerinn, Sylvain; Boisselier, Elodie. (2025) A standardized in vivo protocol for ocular biodistribution of gold nanoparticles. EXPERIMENTAL EYE RESEARCH. DOI 10.1016/j.exer.2025.110409 (http://dx.doi.org/10.1016/j.exer.2025.110409)

Scarrone, Martina; Turner, Dann; Dion, Moira; Tremblay, Denise; Moineau, Sylvain. (2025) In silico and in vitro comparative analysis of 79 Acinetobacter baumannii clinical isolates. MICROBIOLOGY SPECTRUM. DOI 10.1128/spectrum.02849-24 (http://dx.doi.org/10.1128/spectrum.02849-24)

Abdallah, Khaled; Fliss, Omar; Pham, Nguyen, Phuong; Guay, Louis, David; Gingras, Helene; Godin, Chantal; Leprohon, Philippe; Biron, Eric; Fliss, Ismail; Ouellette, Marc. (2025) Antimicrobial Activity of a Synthetic Brevibacillin Analog Against Multidrug-Resistant Campylobacter spp.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. DOI 10.3390/ijms26104657 (http://dx.doi.org/10.3390/ijms26104657)

Brito, Ivanildo, A.; Rosa, Matheus, E.; Boisselier, Elodie; Albuquerque, Vanessa; Tempone, Andre, G.; Caseli, Luciano; Lago, Joao Henrique, G. (2025) Anti-Trypanosoma cruzi Effect of Fatty Acids from Porcelia macrocarpa Is Related to Interactions of Cell Membranes at Different Microdomains as Assessed Using Langmuir Monolayers. ACS OMEGA. DOI 10.1021/acsomega.5c01382 (http://dx.doi.org/10.1021/acsomega.5c01382)

Manica, Fabiana, M.; Campesato, Luis Felipe, I.; Scholl, Juliete, Nathali; Braganhol,, Elizandra; Bergamin, Leticia, S.; Edelweiss, Maria Isabel, A.; Lenz,, Guido; Sevigny, Jean; Figueiro, Fabricio; Battastini, Ana Maria, O. (2025) Assessing Ecto-5'-Nucleotidase/CD73 Expression and Malignancy Parameters in Early- and Late- Passage C6 Glioma Cells. NEUROCHEMICAL RESEARCH. DOI 10.1007/s11064-025-04409-8 (http://dx.doi.org/10.1007/s11064-025-04409-8)

Belda, Hugo; Bradley, David; Christodoulou, Evangelos; Nofal, Stephanie, D.; Broncel, Malgorzata; Jones, David; Davies, Heledd; Bertran, M., Teresa; Purkiss, Andrew, G.; Ogrodowicz, Roksana, W.; Joshi, Dhira; O'Reilly, Nicola; Walport, Louise; Powell, Andrew; House, David; Kjaer, Svend; Claessens, Antoine; Landry, Christian, R.; Treeck, Moritz. (2025) The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound. NATURE MICROBIOLOGY. DOI 10.1038/s41564-025-02017-4 (http://dx.doi.org/10.1038/s41564-025-02017-4)

Amina, Bibi; Nawaz, Ismat; Rai, Damita; Sevigny, Jean; Hussain, Tajamul; Alrokayan, Salman; Muhammad, Muhammad; Huang, Qing; Iqbal, Jamshed. (2025) Design, synthesis and in vitro and in silico evaluation of novel nalidixic acid derivatives as potent ectonucleotidases inhibitors. JOURNAL OF MOLECULAR STRUCTURE. DOI 10.1016/j.molstruc.2025.142611 (http://dx.doi.org/10.1016/j.molstruc.2025.142611)

Zhang, Yichang; Castro-Mejia, Josue, L.; Deng, Ling; Shah, Shiraz, A.; Thorsen,, Jonathan; Rodriguez, Cristina, Leal; Jessen, Leon, E.; Dion, Moira, B.; Chawes, Bo; Bonnelykke, Klaus; Sorensen, Soren, J.; Bisgaard, Hans; Moineau, Sylvain; Petit, Marie-Agnes; Stokholm, Jakob; Nielsen, Dennis, S. (2025) The influence of early life exposures on the infant gut virome. GUT MICROBES. DOI 10.1080/19490976.2025.2501194 (http://dx.doi.org/10.1080/19490976.2025.2501194)

Rahman, Md Ramim, Tanver; Guay, Louis-David; Fliss, Ismail; Biron, Eric. (2025) Structure-Activity Study of the Antimicrobial Lipopeptide Humimycin A and Screening Against Multidrug-Resistant Staphylococcus aureus. ANTIBIOTICS-BASEL. DOI 10.3390/antibiotics14040385 (http://dx.doi.org/10.3390/antibiotics14040385)

Burchell-Reyes, Kelly; Paquin, Jean-Francois. (2025) Fluorohydrins and where to find them: recent asymmetric syntheses of β-fluoro alcohols and their derivatives. ORGANIC & BIOMOLECULAR CHEMISTRY. DOI 10.1039/d5ob00330j (http://dx.doi.org/10.1039/d5ob00330j)

Barra,, Lillian; Saunders, Sheri; Mangion, Mathias; Pare,, Guillaume; Maaroufi, Halim; Garnier, Alain; Cairns, Ewa; Fernandes, Maria, J. (2025) Identification of autoantibodies targeting citrullinated CLEC12A in rheumatoid arthritis patients. JOURNAL OF TRANSLATIONAL AUTOIMMUNITY. DOI 10.1016/j.jtauto.2025.100287 (http://dx.doi.org/10.1016/j.jtauto.2025.100287)

Piche, Laurie, C.; Bories, Sophie; Liato, Viacheslav; Paquet, Valerie, E.; Saucier, Linda; Letourneau-Montminy, Marie-Pierre; Charette, Steve, J.; Dubar, Rodrigue; Labrie, Simon, J.; Lague, Patrick; Vincent, Antony, T. (2025) Evolutionary responses of Escherichia coli to phage pressure: insights into mucoidy and colanic acid overexpression. BMC GENOMICS. DOI 10.1186/s12864-025-11605-x (http://dx.doi.org/10.1186/s12864-025-11605-x)

Kang, Bong, Gu; Kang, Sung-Ung; Kim, Jae, Jin; Kwon, Ji-Sun; Gagne, Jean-Philippe; Lee, Seo, Yun; Kim, Soyeon; Lee, Karl, S.; Ha, Shinwon; Jeong, Jun, Seop; Lee, Yun-Il; Zhu,, Heng; Kim, Dongsan; Poirier, Guy, G.; Kang, Ho, Chul; Dawson, Valina, L.; Dawson, Ted, M. (2025) Proteome-wide microarray-based screening of PAR-binding proteins. NUCLEIC ACIDS RESEARCH. DOI 10.1093/nar/gkaf300 (http://dx.doi.org/10.1093/nar/gkaf300)

Cisneros, Angel, F.; Landry, Christian, R.. (2025) Simple genetic mechanisms toward more intricate molecular complexes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. DOI 10.1073/pnas.2500162122 (http://dx.doi.org/10.1073/pnas.2500162122)

Millette, Marc-Antoine; Coutinho, Ana; Prieto, Manuel; Salesse, Christian. (2025) Role of the Palmitoyl Group and of the Amphipathic α Helix in the Membrane Binding of the C-Terminus of G-Protein Receptor Kinase 4α/β. BIOCHEMISTRY. DOI 10.1021/acs.biochem.4c00492 (http://dx.doi.org/10.1021/acs.biochem.4c00492)

Tchara, Pata-Eting, Kougnassoukou; Loehr, Jeremy; Lambert, Jean-Philippe. (2025) Coupling Proximity Biotinylation with Genomic Targeting to Characterize Locus-Specific Changes in Chromatin Environments. JOURNAL OF PROTEOME RESEARCH. DOI 10.1021/acs.jproteome.4c00931 (http://dx.doi.org/10.1021/acs.jproteome.4c00931)

Vann, Kendra, R.; Sharma, Rajal; Hsu, Chih-Chao; Devoucoux, Maeva; Tencer, Adam, H.; Zeng, Lei; Lin, Kevin; Zhu, Li; Li, Qin; Lachance, Catherine; Ospina, Ruben, Rosas; Tong, Qiong; Cheung, Ka, Lung; Yang, Shuai; Biswas, Soumi; Xuan, Hongwen; Gatchalian, Jovylyn; Alamillo, Lorena; Wang, Jianlong; Jang, Suk, Min; Klein, Brianna, J.; Lu, Yue; Ernst, Patricia; Strahl, Brian, D.; Rothbart, Scott, B.; Walsh, Martin, J.; Cleary, Michael, L.; Cote, Jacques; Shi, Xiaobing; Zhou, Ming-Ming; Kutateladze, Tatiana, G.. (2025) Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation. NATURE COMMUNICATIONS. DOI 10.1038/s41467-025-57556-5 (http://dx.doi.org/10.1038/s41467-025-57556-5)

Mosterd, Cas; Moineau, Sylvain. (2025) Insight into crRNA Processing in Streptococcus mutans P42S and Application of SmutCas9 in Genome Editing. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. DOI 10.3390/ijms26052005 (http://dx.doi.org/10.3390/ijms26052005)

Cashman-Kadri, Samuel; Fliss, Ismail; Beaulieu, Lucie; Lague, Patrick. (2025) Ergosterol depletion by fish AMP analogs likely enhances fungal membrane permeability. BIOPHYSICAL JOURNAL. DOI 10.1016/j.bpj.2025.02.015 (http://dx.doi.org/10.1016/j.bpj.2025.02.015)

Silva, Luiz Fernando, Lopes; Scholl, Juliete, Nathali; Weber, Augusto, Ferreira; Dias, Camila, Kehl; Pizzato, Pauline, Rafaela; Lima, Vinicius, Pierdona; Sévigny, Jean; Battastini, Ana Maria, Oliveira; Figueiro, Fabricio. (2025) Assessing the impact of CD73 inhibition on overcoming anti-EGFR resistance in glioma cells. ONCOLOGY RESEARCH. DOI 10.32604/or.2024.055508 (http://dx.doi.org/10.32604/or.2024.055508)

Boccacci, Yelena; Dumont, Nellie; Doyon, Yannick; Laganiere, Josée. (2025) CRISPR-Cas9-driven antigen conversion of clinically relevant blood group systems. HUMAN MOLECULAR GENETICS. DOI 10.1093/hmg/ddaf040 (http://dx.doi.org/10.1093/hmg/ddaf040)

Raiche-Marcoux, Gabrielle; Methot, Sebastien; Tchatchouang, Ange; Bettoli, Camille; Maranda, Cloe; Loiseau, Alexis; Proulx, Stephanie; Rochette, Patrick, J.; Genin, Emilie; Boisselier, Élodie. (2025) Localization of fluorescent gold nanoparticles throughout the eye after topical administration. FRONTIERS IN MEDICINE. DOI 10.3389/fmed.2025.1557611 (http://dx.doi.org/10.3389/fmed.2025.1557611)

Lau, Hayley, R.; Smith, Hayley, S.; Alural, Begum; Martin, Claire, E.; New, Laura, A.; Tilak, Manali; Banerjee, Sara, L.; Robeson, Hannah, N.; Bisson, Nicolas; Gingras, Anne-Claude; Lalonde, Jasmin; Jones, Nina. (2025) ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling. MOLECULAR ONCOLOGY. DOI 10.1002/1878-0261.70022 (http://dx.doi.org/10.1002/1878-0261.70022)

Bi, Chunyang; Mirza, Salahuddin; Baburi, Helay; Schaekel, Laura; Winzer, Riekje; Moschuetz, Susanne; Keetz, Kilian; Lopez, Vittoria; Pelletier, Julie; Sevigny, Jean; zur Wiesch, Julian, Schulze; Claff, Tobias; Tolosa, Eva; Namasivayam, Vigneshwaran; Straeter, Norbert; Mueller, Christa, E.. (2025) Synthesis, Characterization, Interactions, and Immunomodulatory Function of Ectonucleotidase CD39/CD73 Inhibitor 8-Butylthioadenosine 5′-Monophosphate. ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE. DOI 10.1021/acsptsci.5c00126 (http://dx.doi.org/10.1021/acsptsci.5c00126)

Verret, Laurianne; Burchell-Reyes, Kelly ; Morin, Jean-Francois ; Paquin, Jean-Francois. (2025) Exploration of 2-(pentafluoro-λ6-sulfanyl)ethane-1-sulfonyl chloride as a novel pentafluorosulfanylation reagent. JOURNAL OF FLUORINE CHEMISTRY. DOI 10.1016/j.jfluchem.2024.110387 (http://dx.doi.org/10.1016/j.jfluchem.2024.110387)

Bahadori, Sam; Leclerc, Christina; St-Gelais, Jacob; Poulin, Guillaume; Giguere, Denis. (2025) Catalyst-Controlled, Site-Selective Functionalization of Levoglucosan Analogues Mediated by Chiral Zinc Diamine Complexes. JOURNAL OF ORGANIC CHEMISTRY. DOI: 10.1021/acs.joc.4c02681 (http:dx.doi.org/10.1021/acs.joc.4c02681)

Prifti, Diogjena Katerina; Lauzier, Annie; Garand, Chantal; Calvo, Eva; Devillers, Romain; Roy, Suparba; Dos Santos, Alexsandro; Descombes, Laurence; Trudel, Benjamin; Laplante, Mathieu; Bordeleau, Francois; Elowe, Sabine. (2025) ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression. JOURNAL OF CELL BIOLOGY. DOI: 10.1083/jcb.202311194 (http:dx.doi.org/10.1083/jcb.202311194)

Mamjoud, Amal; Zirah, Severine; Biron, Eric; Fliss, Omar; Fliss, Ismail. (2025) In Vitro Insights into Bacteriocin-Mediated Modulation of Chicken Cecal Microbiota. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. DOI : 10.3390/ijms26020755 (http:dx.doi.org/10.3390/ijms26020755)

Berger, Marie-Rose Ouellet-Du; Bouillon, Jean-Philippe; Paquin, Jean-Francois. (2025) Exploration towards the bromopentafluorosulfanylation reaction of terminal alkynes. JOURNAL OF FLUORINE CHEMISTRY. DOI: 10.1016/j.jfluchem.2024.110386 (http:dx.doi.org/10.1016/j.jfluchem.2024.110386)

Provencher, Luc; Nartey, Wilson; Brownlee, Peter M.; Atkins, Austin W.; Gagne, Jean-Philippe; Baudrier, Lou; Ting, Nicholas S. Y.;Piett, Cortt G.; Fang, Shujuan; Pearson, Dustin D.; Moore, Shaun; illon, Pierre; Nagel, Zachary D.; Poirier, Guy G.; Williams, Gareth J. ; Goodarzi, Aaron A. (2025) CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair. NATURE COMMUNICATIONS. DOI: 10.1038/s41467-025-56085-5 (http:dx.doi.org/10.1038/s41467-025-56085-5)

Kumar, Kiran; Arnold, Alexandre A.; Gauthier, Raphael; Mamone, Marius; Paquin, Jean-Francois; Warschawski, Dror E.; Marcotte, Isabelle. (2025) Simultaneous assessment of membrane bilayer structure and drug insertion by 19F solid-state NMR. BIOPHYSICAL JOURNAL. DOI: 10.1016/j.bpj.2024.11.3319 (http:dx.doi.org/10.1016/j.bpj.2024.11.3319)

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