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Publications 2020

Afzal, Saira; Al-Rashida, Mariya; Hameed, Abdul; Pelletier, Julie; Sevigny, Jean; Iqbal, Jamshed. (2020). Functionalized Oxoindolin Hydrazine Carbothioamide Derivatives as Highly Potent Inhibitors of Nucleoside Triphosphate Diphosphohydrolases. FRONTIERS IN PHARMACOLOGY. DOI: 10.3389/fphar.2020.585876 (http://dx.doi.org/10.3389/fphar.2020.585876)

Berube, Christopher; Borgia, Alexandre; Gagnon, Dominic; Mukherjee, Angana; Richard, Dave; Voyer, Normand. (2020). Total Synthesis and Antimalarial Activity of Dominicin, a Cyclic Octapeptide from a Marine Sponge. JOURNAL OF NATURAL PRODUCTS. DOI: 10.1021/acs.jnatprod.9b00936 (http://dx.doi.org/10.1021/acs.jnatprod.9b00936)

Baqi, Younis; Rashed, Mahmoud; Schaekel, Laura; Malik, Enas M.; Pelletier, Julie; Sevigny, Jean; Fiene, Amelie; Mueller, Christa E.. (2020). Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3. FRONTIERS IN PHARMACOLOGY. DOI: 10.3389/fphar.2020.01282 (http://dx.doi.org/10.3389/fphar.2020.01282)

Lammers, Monica D.; Aneli, Nyasmin M.; de Oliveira, Gabriela G.; de Oliveira Maciel, Sarah F., V; Zanini, Daniela; Manica, Aline; de Resende e Silva, Debora T.; Bagatini, Margarete D.; Sevigny, Jean; De Sa, Clodoaldo A.; Manfredi, Leandro H.; Cardoso, Andreia M.. (2020). The anti-inflammatory effect of resistance training in hypertensive women: the role of purinergic signaling. JOURNAL OF HYPERTENSION. DOI: 10.1097/HJH.0000000000002578 (http://dx.doi.org/10.1097/HJH.0000000000002578)

Azambuja, J. H.; Schuh, R. S.; Michels, L. R.; Gelsleichter, N. E.; Beckenkamp, L. R.; Iser, I. C.; Lenz, G. S.; De Oliveira, F. H.; Venturin, G.; Greggio, S.; DaCosta, J. C.; Wink, M. R.; Sevigny, J.; Stefani, M. A.; Battastini, A. M. O.; Teixeira, H. F.; Braganhol, E.. (2020). Nasal Administration of Cationic Nanoemulsions as CD73-siRNA Delivery System for Glioblastoma Treatment: a New Therapeutical Approach. MOLECULAR NEUROBIOLOGY. DOI: 10.1007/s12035-019-01730-6 (http://dx.doi.org/10.1007/s12035-019-01730-6)

Nabeel-Shah, Syed; Ashraf, Kanwal; Saettone, Alejandro; Garg, Jyoti; Derynck, Joanna; Lambert, Jean-Philippe; Pearlman, Ronald E.; Fillingham, Jeffrey. (2020). Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila. SCIENTIFIC REPORTS. DOI: 10.1038/s41598-019-56867-0 (http://dx.doi.org/10.1038/s41598-019-56867-0)

Levesque, Sebastien; Agudelo, Daniel; Doyon, Yannick. (2020). Rewired Cas9s with Minimal Sequence Constraints. TRENDS IN PHARMACOLOGICAL SCIENCES. DOI: 10.1016/j.tips.2020.04.009 (http://dx.doi.org/10.1016/j.tips.2020.04.009)

Schaekel, Laura; Schmies, Constanze C.; Idris, Riham M.; Luo, Xihuan; Lee, Sang-Yong; Lopez, Vittoria; Mirza, Salahuddin; Vu, The Hung; Pelletier, Julie; Sevigny, Jean; Namasivayam, Vigneshwaran; Mueller, Christa E.. (2020). Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors. FRONTIERS IN PHARMACOLOGY. DOI: 10.3389/fphar.2020.01294 (http://dx.doi.org/10.3389/fphar.2020.01294)

Teixeira, Fernanda C.; Bruxel, Fernanda; Azambuja, Juliana H.; Berenguer, Alexandre M.; Stefani, Marco A.; Sevigny, Jean; Spanevello, Roselia M.; Battastini, Ana M. O.; Teixeira, Helder F.; Braganhol, Elizandra. (2020). Development and characterization of CD73-siRNA-loaded nanoemulsion: effect on C6 glioma cells and primary astrocytes. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY. DOI: 10.1080/10837450.2019.1705485 (http://dx.doi.org/10.1080/10837450.2019.1705485)

Lemay, Marie-Laurence; Maass, Sandra; Otto, Andreas; Hamel, Jeremie; Plante, Pier-Luc; Rousseau, Genevieve M.; Tremblay, Denise M.; Shi, Rong; Corbeil, Jacques; Gagne, Stephane M.; Becher, Doerte; Moineau, Sylvain. (2020). A Lactococcal Phage Protein Promotes Viral Propagation and Alters the Host Proteomic Response During Infection. VIRUSES-BASEL. DOI: 10.3390/v12080797 (http://dx.doi.org/10.3390/v12080797)

Mathieu, Aurelie; Dion, Moira; Deng, Ling; Tremblay, Denise; Moncaut, Elisabeth; Shah, Shiraz A.; Stokholm, Jakob; Krogfelt, Karen A.; Schjorring, Susanne; Bisgaard, Hans; Nielsen, Dennis S.; Moineau, Sylvain; Petit, Marie-Agnes. (2020). Virulent coliphages in 1-year-old children fecal samples are fewer, but more infectious than temperate coliphages. NATURE COMMUNICATIONS. DOI: 10.1038/s41467-019-14042-z (http://dx.doi.org/10.1038/s41467-019-14042-z)

Kothari, Charu; Osseni, Mazid Abiodoun; Agbo, Lynda; Ouellette, Genevieve; Deraspe, Maxime; Laviolette, Francois; Corbeil, Jacques; Lambert, Jean-Philippe; Diorio, Caroline; Durocher, Francine. (2020). Machine learning analysis identifies genes differentiating triple negative breast cancers. SCIENTIFIC REPORTS. DOI: 10.1038/s41598-020-67525-1 (http://dx.doi.org/10.1038/s41598-020-67525-1)

Despres, Philippe C.; Dube, Alexandre K.; Seki, Motoaki; Yachie, Nozomu; Landry, Christian R.. (2020). Perturbing proteomes at single residue resolution using base editing. NATURE COMMUNICATIONS. DOI: 10.1038/s41467-020-15796-7 (http://dx.doi.org/10.1038/s41467-020-15796-7)

Azambuja, J. H.; Schuh, R. S.; Michels, L. R.; Iser, I. C.; Beckenkamp, L. R.; Roliano, G. G.; Lenz, G. S.; Scholl, J. N.; Sevigny, J.; Wink, M. R.; Stefani, M. A.; Battastini, A. M. O.; Figueiro, F.; Teixeira, H. F.; Braganhol, E.. (2020). Blockade of CD73 delays glioblastoma growth by modulating the immune environment. CANCER IMMUNOLOGY IMMUNOTHERAPY. DOI: 10.1007/s00262-020-02569-w (http://dx.doi.org/10.1007/s00262-020-02569-w)

Lemay, Marie-Laurence; Moineau, Sylvain. (2020). How are genes modified? Crossbreeding, mutagenesis, and CRISPR-Cas9. GENETICALLY MODIFIED AND IRRADIATED FOOD: CONTROVERSIAL ISSUES: FACTS VERSUS PERCEPTIONS. DOI: 10.1016/B978-0-12-817240-7.00003-6 (http://dx.doi.org/10.1016/B978-0-12-817240-7.00003-6)

Cooke, Steven; Nguyen, Vivian M.; Anastakis, Dimitry; Scott, Shannon D.; Turetsky, Merritt R.; Amirfazli, Alidad; Hearn, Alison; Milton, Cynthia E.; Loewen, Laura; Smith, Eric E.; Norris, D. Ryan; Lavoie, Kim L.; Aiken, Alice; Ansari, Daniel; Antle, Alissa; Babel, Molly; Bailey, Jane; Bernstein, Daniel M.; Birnbaum, Rachel; Bourassa, Carrie; Calcagno, Antonio; Campana, Aurelie; Chen, Bing; Collins, Karen; Connelly, Catherine E.; Denov, Myriam; Dupont, Benoit; George, Eric; Gregory-Eaves, Irene; High, Steven; Hill, Josephine M.; Jackson, Philip L.; Jette, Nathalie; Jurdjevic, Mark; Kothari, Anita; Khairy, Paul; Lamoureux, Sylvie A.; Ladner, Kiera; Landry, Christian R.; Legare, Francois; Lehoux, Nadia; Leuprecht, Christian; Lieverse, Angela R.; Luczak, Artur; Mallory, Mark L.; Manning, Erin; Mazalek, Ali; Murray, Stuart J.; Newman, Lenore L.; Oosterveld, Valerie; Potvin, Patrice; Reimer-Kirkham, Sheryl; Rowsell, Jennifer; Stacey, Dawn; Tighe, Susan; Vocadlo, David J.; Wilson, Anne E.; Woolford, Andrew. (2020). Diverse perspectives on interdisciplinarity from Members of the College of the Royal Society of Canada. FACETS. DOI: 10.1139/facets-2019-0044 (http://dx.doi.org/10.1139/facets-2019-0044)

Younus, Hafiza Amna; Hameed, Abdul; Mahmood, Abid; Khan, Muhammad Siraj; Saeed, Muhammad; Batool, Farwa; Asari, Asnuzilawati; Mohamad, Habsah; Pelletier, Julie; Sevigny, Jean; Iqbal, Jamshed; al-Rashida, Mariya. (2020). Sulfonylhydrazones: Design, synthesis and investigation of ectonucleotidase (ALP & e5?NT) inhibition activities. BIOORGANIC CHEMISTRY. DOI: 10.1016/j.bioorg.2020.103827 (http://dx.doi.org/10.1016/j.bioorg.2020.103827)

Ferreira, Maria Tedim; Berger, Louise; Rouleau, Michele; Poirier, Guy G.. (2020). Assessment of PARP-1 Distribution in Tissues of Cynomolgus Monkeys. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. DOI: 10.1369/0022155420926022 (http://dx.doi.org/10.1369/0022155420926022)

Herman-de-Sousa, Carina; Pinheiro, Ana Rita; Paramos-de-Carvalho, Diogo; Costa, Maria Adelina; Ferreirinha, Fatima; Magalhaes-Cardoso, Teresa; Ribeiro, Severino; Pelletier, Julie; Sevigny, Jean; Correia-de-Sa, Paulo. (2020). Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers. CELLS. DOI: 10.3390/cells9030651 (http://dx.doi.org/10.3390/cells9030651)

Zhang, Heng; Devoucoux, Maeva; Song, Xiaosheng; Li, Li; Ayaz, Gamze; Cheng, Harry; Tempel, Wolfram; Dong, Cheng; Loppnau, Peter; Cote, Jacques; Min, Jinrong. (2020). Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex. CELL REPORTS. DOI: 10.1016/j.celrep.2020.03.003 (http://dx.doi.org/10.1016/j.celrep.2020.03.003)

Braga, Luciano Gama; Cisneros, Angel F.; Mathieu, Michelle M.; Clerc, Maxime; Garcia, Pauline; Lottin, Baptiste; Garand, Chantal; Thebault, Philippe; Landry, Christian R.; Elowe, Sabine. (2020). BUBR1 Pseudokinase Domain Promotes Kinetochore PP2A-B56 Recruitment, Spindle Checkpoint Silencing, and Chromosome Alignment. CELL REPORTS. DOI: 10.1016/j.celrep.2020.108397 (http://dx.doi.org/10.1016/j.celrep.2020.108397)

Beckenkamp, L. R.; da Fontoura, D. M. S.; Korb, V. G.; de Campos, R. P.; Onzi, G. R.; Iser, I. C.; Bertoni, A. P. S.; Sevigny, J.; Lenz, G.; Wink, Marcia Rosangela. (2020). Immortalization of Mesenchymal Stromal Cells by TERT Affects Adenosine Metabolism and Impairs their Immunosuppressive Capacity. STEM CELL REVIEWS AND REPORTS. DOI: 10.1007/s12015-020-09986-5 (http://dx.doi.org/10.1007/s12015-020-09986-5)

Scholl, Juliete Nathali; Dias, Amanda de Fraga; Pizzato, Pauline Rafaela; Lopes, Daniela Vasconcelos; Jacintho Moritz, Cesar Eduardo; Farias Jandrey, Elisa Helena; Souto, Gabriele Dadalt; Colombo, Mariana; Rohden, Francieli; Sevigny, Jean; Pohlmann, Adriana Raffin; Guterres, Silvia Staniscuaski; Oliveira Battastini, Ana Maria; Figueiro, Fabricio. (2020). Characterization and antiproliferative activity of glioma-derived extracellular vesicles. NANOMEDICINE. DOI: 10.2217/nnm-2019-0431 (http://dx.doi.org/10.2217/nnm-2019-0431)

Philippe, Cecile; Levesque, Sebastien; Dion, Moira B.; Tremblay, Denise M.; Horvath, Philippe; Lueth, Natascha; Cambillau, Christian; Franz, Charles; Neve, Horst; Fremaux, Christophe; Heller, Knut J.; Moineau, Sylvain. (2020). Novel Genus of Phages Infecting Streptococcus thermophilus: Genomic and Morphological Characterization. APPLIED AND ENVIRONMENTAL MICROBIOLOGY. DOI: 10.1128/AEM.00227-20 (http://dx.doi.org/10.1128/AEM.00227-20)

Gao, Ruimin; Naushad, Sohail; Moineau, Sylvain; Levesque, Roger; Goodridge, Lawrence; Ogunremi, Dele. (2020). Comparative genomic analysis of 142 bacteriophages infecting Salmonella enterica subsp. enterica. BMC GENOMICS. DOI: 10.1186/s12864-020-6765-z (http://dx.doi.org/10.1186/s12864-020-6765-z)

Henault, Mathieu; Marsit, Souhir; Charron, Guillaume; Landry, Christian R.. (2020). The effect of hybridization on transposable element accumulation in an undomesticated fungal species. ELIFE. DOI: 10.7554/eLife.60474 (http://dx.doi.org/10.7554/eLife.60474)

Lamaa, Assala; Humbert, Jonathan; Aguirrebengoa, Marion; Cheng, Xue; Nicolas, Estelle; Cote, Jacques; Trouche, Didier. (2020). Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation. ELIFE. DOI: 10.7554/eLife.53375 (http://dx.doi.org/10.7554/eLife.53375)

Willig, Julia Biz; Barreto Vianna, Debora Renz; Beckenkamp, Aline; Beckenkamp, Liziane Raquel; Sevigny, Jean; Wink, Marcia Rosangela; Buffon, Andreia; Pilger, Diogo Andre. (2020). Imatinib mesylate affects extracellular ATP catabolism and expression of NTPDases in a chronic myeloid leukemia cell line. PURINERGIC SIGNALLING. DOI: 10.1007/s11302-019-09686-x (http://dx.doi.org/10.1007/s11302-019-09686-x)

Aziz, Hamid; Mahmood, Abid; Zaib, Sumera; Saeed, Aamer; Shafiq, Zahid; Pelletier, Julie; Sevigny, Jean; Iqbal, Jamshed. (2020). Synthesis, characterization, in vitro tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) inhibition studies and computational evaluation of novel thiazole derivatives. BIOORGANIC CHEMISTRY. DOI: 10.1016/j.bioorg.2020.104088 (http://dx.doi.org/10.1016/j.bioorg.2020.104088)

Ullah, Saif; El-Gamal, Mohammed, I; Zaib, Sumera; Anbar, Hanan S.; Zaraei, Seyed-Omar; Sbenati, Rawan M.; Pelletier, Julie; Sevigny, Jean; Oh, Chang-Hyun; Iqbal, Jamshed. (2020). Synthesis, biological evaluation, and docking studies of new pyrazole-based thiourea and sulfonamide derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase. BIOORGANIC CHEMISTRY. DOI: 10.1016/j.bioorg.2020.103783 (http://dx.doi.org/10.1016/j.bioorg.2020.103783)

Andleeb, Hina; Hussain, Muzammal; Ejaz, Syeda Abida; Sevigny, Jean; Farman, Muhammad; Yasinzai, Masoom; Zhang, Jiancun; Iqbal, Jamshed; Hameed, Shahid. (2020). Synthesis and computational studies of highly selective inhibitors of human recombinant tissue non-specific alkaline phosphatase (h-TNAP): A therapeutic target against vascular calcification. BIOORGANIC CHEMISTRY. DOI: 10.1016/j.bioorg.2020.103999 (http://dx.doi.org/10.1016/j.bioorg.2020.103999)

Anbar, Hanan S.; El-Gamal, Randa; Ullah, Saif; Zaraei, Seyed-Omar; al-Rashida, Mariya; Zaib, Sumera; Pelletier, Julie; Sevigny, Jean; Iqbal, Jamshed; El-Gamal, Mohammed I.. (2020). Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents. BIOORGANIC CHEMISTRY. DOI: 10.1016/j.bioorg.2020.104305 (http://dx.doi.org/10.1016/j.bioorg.2020.104305)

Ashraf, Abida; Shafiq, Zahid; Jadoon, Muhammad Siraj Khan; Tahir, Muhammad Nawaz; Pelletier, Julie; Sevigny, Jean; Yaqub, Muhammad; Iqbal, Jamshed. (2020). Synthesis, Characterization, and In Silico Studies of Novel Spirooxindole Derivatives as Ecto-5′-Nucleotidase Inhibitors. ACS MEDICINAL CHEMISTRY LETTERS. DOI: 10.1021/acsmedchemlett.0c00343 (http://dx.doi.org/10.1021/acsmedchemlett.0c00343)

Mumtaz, Amara; Saeed, Kiran; Mahmood, Abid; Zaib, Sumera; Saeed, Aamer; Pelletier, Julie; Sevigny, Jean; Iqbal, Jamshed. (2020). Bisthioureas of pimelic acid and 4-methylsalicylic acid derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP): Synthesis and molecular docking studies. BIOORGANIC CHEMISTRY. DOI: 10.1016/j.bioorg.2020.103996 (http://dx.doi.org/10.1016/j.bioorg.2020.103996)

Pelletier, Julie; Agonsanou, Herve; Manica, Fabiana; Lavoie, Elise G.; Salem, Mabrouka; Luyindula, Patrick; Babou Kammoe, Romuald Brice; Sevigny, Jean. (2020). A Simple and Efficient Genetic Immunization Protocol for the Production of Highly Specific Polyclonal and Monoclonal Antibodies against the Native Form of Mammalian Proteins. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. DOI: 10.3390/ijms21197074 (http://dx.doi.org/10.3390/ijms21197074)

Simon, Gaelle; Berube, Christopher; Paquet-Cote, Pierre-Alexandre; Grenier, Daniel; Voyer, Normand. (2020). Preventing Candida albicans biofilm formation using aromatic-rich piperazines. BIOORGANIC & MEDICINAL CHEMISTRY. DOI: 10.1016/j.bmc.2020.115810 (http://dx.doi.org/10.1016/j.bmc.2020.115810)

Maltais, Rene; Djiemeny, Adrien Ngueta; Roy, Jenny; Barbeau, Xavier; Lambert, Jean-Philippe; Poirier, Donald. (2020). Design and synthesis of dansyl-labeled inhibitors of steroid sulfatase for optical imaging. BIOORGANIC & MEDICINAL CHEMISTRY. DOI: 10.1016/j.bmc.2020.115368 (http://dx.doi.org/10.1016/j.bmc.2020.115368)

Louphrasitthiphol, Pakavarin; Siddaway, Robert; Loffreda, Alessia; Pogenberg, Vivian; Friedrichsen, Hans; Schepsky, Alexander; Zeng, Zhiqiang; Lu, Min; Strub, Thomas; Freter, Rasmus; Lisle, Richard; Suer, Eda; Thomas, Benjamin; Schuster-Bockler, Benjamin; Filippakopoulos, Panagis; Middleton, Mark; Lu, Xin; Patton, E. Elizabeth; Davidson, Irwin; Lambert, Jean-Philippe; Wilmanns, Matthias; Steingrimsson, Eirikur; Mazza, Davide; Goding, Colin R.. (2020). Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution. MOLECULAR CELL. DOI: 10.1016/j.molcel.2020.05.025 (http://dx.doi.org/10.1016/j.molcel.2020.05.025)

Agudelo, Daniel; Carter, Sophie; Velimirovic, Minja; Duringer, Alexis; Rivest, Jean-Francois; Levesque, Sebastien; Loehr, Jeremy; Mouchiroud, Mathilde; Cyr, Denis; Waters, Paula J.; Laplante, Mathieu; Moineau, Sylvain; Goulet, Adeline; Doyon, Yannick. (2020). Versatile and robust genome editing with Streptococcus thermophilus CRISPR1-Cas9. GENOME RESEARCH. DOI: 10.1101/gr.255414.119 (http://dx.doi.org/10.1101/gr.255414.119)

Klein, Brianna J.; Cox, Khan L.; Jang, Suk Min; Cote, Jacques; Poirier, Michael G.; Kutateladze, Tatiana G.. (2020). Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin. STRUCTURE. DOI: 10.1016/j.str.2019.10.014 (http://dx.doi.org/10.1016/j.str.2019.10.014)

Paquet-Cote, Pierre-Alexandre; Paradis, Jean-Philippe; Auger, Michele; Voyer, Normand. (2020). Crown ether modified peptides: Length and crown ring size impact on membrane interactions. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. DOI: 10.1016/j.bbamem.2020.183261 (http://dx.doi.org/10.1016/j.bbamem.2020.183261)

Kot, Witold; Olsen, Nikoline S.; Nielsen, Tue K.; Hutinet, Geoffrey; de Crecy-Lagard, Valerie; Cui, Liang; Dedon, Peter C.; Carstens, Alexander B.; Moineau, Sylvain; Swairjo, Manal A.; Hansen, Lars H.. (2020). Detection of preQ0 deazaguanine modifications in bacteriophage CAjan DNA using Nanopore sequencing reveals same hypermodification at two distinct DNA motifs. NUCLEIC ACIDS RESEARCH. DOI: 10.1093/nar/gkaa735 (http://dx.doi.org/10.1093/nar/gkaa735)

Kiepas, Alex; Voorand, Elena; Senecal, Julien; Ahn, Ryuhjin; Annis, Matthew G.; Jacquet, Kevin; Tali, George; Bisson, Nicolas; Ursini-Siegel, Josie; Siegel, Peter M.; Brown, Claire M.. (2020). The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation. JOURNAL OF BIOLOGICAL CHEMISTRY. DOI: 10.1074/jbc.RA119.011903 (http://dx.doi.org/10.1074/jbc.RA119.011903)

Pham, Van Dung; To, Tuan Anh; Gagne-Thivierge, Cynthia; Couture, Manon; Lague, Patrick; Yao, Deqiang; Picard, Marie-Eve; Lortie, Louis-Andre; Attere, Sabrina A.; Zhu, Xiaojun; Levesque, Roger C.; Charette, Steve J.; Shi, Rong. (2020). Structural insights into the putative bacterial acetylcholinesterase ChoE and its substrate inhibition mechanism. JOURNAL OF BIOLOGICAL CHEMISTRY. DOI: 10.1074/jbc.RA119.011809 (http://dx.doi.org/10.1074/jbc.RA119.011809)

Manenda, Mahder S.; Picard, Marie-Eve; Zhang, Liping; Cyr, Normand; Zhu, Xiaojun; Barma, Julie; Pascal, John M.; Couture, Manon; Zhang, Changsheng; Shi, Rong. (2020). Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations. JOURNAL OF BIOLOGICAL CHEMISTRY. DOI: 10.1074/jbc.RA119.011212 (http://dx.doi.org/10.1074/jbc.RA119.011212)

Kaplan, Andrew; Andrei, Sebastian A.; Altena, Anna van Regteren; Simas, Tristan; Banerjee, Sara L.; Kato, Nobuo; Bisson, Nicolas; Higuchi, Yusuke; Ottmann, Christian; Fournier, Alyson E.. (2020). Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth. CELL CHEMICAL BIOLOGY. DOI: 10.1016/j.chembiol.2020.02.010 (http://dx.doi.org/10.1016/j.chembiol.2020.02.010)

Tchara, Pata-Eting Kougnassoukou; Filippakopoulos, Panagis; Lambert, Jean-Philippe. (2020). Emerging tools to investigate bromodomain functions. METHODS. DOI: 10.1016/j.ymeth.2019.11.003 (http://dx.doi.org/10.1016/j.ymeth.2019.11.003)

Dos Santos, Alexsandro; Elowe, Sabine. (2020). Moonlighting at the Centrosome: RXRα Turns to Plk1. DEVELOPMENTAL CELL. DOI: 10.1016/j.devcel.2020.11.027 (http://dx.doi.org/10.1016/j.devcel.2020.11.027)

Ahmad, Haseen; Ullah, Saif; Rahman, Fouzia; Saeed, Aamer; Pelletier, Julie; Sevigny, Jean; Hassan, Abbas; Iqbal, Jamshed. (2020). Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and-3 inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. DOI: 10.1016/j.ejmech.2020.112759 (http://dx.doi.org/10.1016/j.ejmech.2020.112759)

Zarrouk, Karima; Van Dung Pham; Piret, Jocelyne; Shi, Rong; Boivin, Guy. (2020). Hypersusceptibility of Human Cytomegalovirus to Foscarnet Induced by Mutations in Helices K and P of the Viral DNA Polymerase. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. DOI: 10.1128/AAC.01910-19 (http://dx.doi.org/10.1128/AAC.01910-19)

Lachance, Gabriel P.; Niyonambaza, Shimwe Dominique; Boisselier, Elodie; Boukadoum, Mounir; Miled, Amine. (2020). Critical Comparison of Sequential and Non-sequential Modes Usage for the Design of a Czerny-Turner Spectrometer. 2020 18TH IEEE INTERNATIONAL NEW CIRCUITS AND SYSTEMS CONFERENCE (NEWCAS'20). DOI: 10.1109/newcas49341.2020.9159788 (http://dx.doi.org/10.1109/newcas49341.2020.9159788)

Dion, Moira B.; Oechslin, Frank; Moineau, Sylvain. (2020). Phage diversity, genomics and phylogeny. NATURE REVIEWS MICROBIOLOGY. DOI: 10.1038/s41579-019-0311-5 (http://dx.doi.org/10.1038/s41579-019-0311-5)

Makarova, Kira S.; Wolf, Yuri, I; Iranzo, Jaime; Shmakov, Sergey A.; Alkhnbashi, Omer S.; Brouns, Stan J. J.; Charpentier, Emmanuelle; Cheng, David; Haft, Daniel H.; Horvath, Philippe; Moineau, Sylvain; Mojica, Francisco J. M.; Scott, David; Shah, Shiraz A.; Siksnys, Virginijus; Terns, Michael P.; Venclovas, Ceslovas; White, Malcolm F.; Yakunin, Alexander F.; Yan, Winston; Zhang, Feng; Garrett, Roger A.; Backofen, Rolf; van der Oost, John; Barrangou, Rodolphe; Koonin, Eugene, V. (2020). Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants. NATURE REVIEWS MICROBIOLOGY. DOI: 10.1038/s41579-019-0299-x (http://dx.doi.org/10.1038/s41579-019-0299-x)

Mosterd, Cas; Moineau, Sylvain. (2020). Characterization of a Type II-A CRISPR-Cas System in Streptococcus mutans. MSPHERE. DOI: 10.1128/mSphere.00235-20 (http://dx.doi.org/10.1128/mSphere.00235-20)

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